Brand Manual Novo Nordisk Pharmaceuticals

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. NovoPen ® Dial-A-Dose Insulin Delivery System Instructions For Use. Open this flap for photos of the NovoPen 3 insulin ® injection system. NovoPen NovoFine ® ® Insulin Delivery Device Disposable Needle Outer needle cap Inner needle cap Pen cap Needle Inspection window Protective tab Insulin scale Cartridge holder PenFill Cartridge (3 mL) Insulin scale ® window Front rubber stopper Threaded plastic cap Piston rod Reset mechanism. Welcome to Your NovoPen ® Dial-A-Dose Insulin Delivery System.

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(See Important Things to Please read it carefully before Know and Important Notes using your NovoPen 3 for the on pages 33-35.) first time. The NovoPen 3 is designed for use with: PenFill 3 mL cartridges.

This booklet gives you Begin by reviewing the photo step-by-step instructions layout of the parts of the for using the NovoPen 3. NovoPen 3, PenFill 3 mL cartridge and NovoFine disposable needle. The inside front cover opens out so you have a handy reference while you read the rest of the booklet. TABLE OF CONTENTS SECTION 1: Preparing the NovoPen 3.5 SECTION 2: Inserting the PenFill 3 mL Cartridge.8 SECTION 3: Attaching the NovoFine Disposable Needle.12 SECTION 4: Doing an Air Shot.16 SECTION 5: Giving the Injection. Gently twist the pen cap until the cap separates from the barrel. Pull the pen cap straight up to remove it. If you use more than one type (N, R or 70/30) of insulin, use a separate NovoPen 3 for each type.

SECTION 1 (cont.) Separate the cartridge holder from the barrel: Unscrew and remove the cartridge holder from the barrel. Make sure the dose indicator window shows zero: Press the push button all the way in until zero (0) appears in the window. The zero should be lined up with the stripe below the dose indicator window. SECTION 1 (cont.) The end of the piston rod should be flat against the end of the reset mechanism prior to inserting each new PenFill 3 mL cartridge.

It should not be sticking out. If the piston rod is sticking out: Turn the end of the reset mechanism in a clockwise direction until it is no. This will prevent the spread of disease. Use only a new PenFill 3 mL cartridge when loading the NovoPen 3.

Never load a partially filled cartridge. Never try to refill a used PenFill 3 mL cartridge. SECTION 2 (cont.) If you use Novolin 70/30 ® 70% NPH, Human Insulin Isophane Suspension & 30% Regular, Human Insulin Injection (recombinant DNA origin) or Novolin N, NPH, ® Human Insulin Isophane Suspension (recombinant DNA origin), mix the insulin: a. Turn the PenFill cartridge up and down between positions A and B, as shown. SECTION 2 (cont.) Insert the PenFill cartridge: Hold the cartridge holder so the wider opening is up.

Drop the PenFill cartridge into the cartridge holder, plastic cap first. A threaded plastic cap surrounds the end of the PenFill cartridge, like the cap on a bottle. In the center is the front rubber stopper. SECTION 2 (cont.) Re-attach the cartridge holder: Screw the barrel into the cartridge holder completely until it is tight. You can see the cartridge in the insulin scale window.

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For your convenience, the cartridge holder has a scale with marks showing approximately how much insulin is left in the PenFill cartridge. SECTION 3 Attaching the NovoFine Disposable Needle At the end of the cartridge holder are two inspection windows. You can see the cartridge through these windows. If you use Novolin 70/30 or Novolin N insulin, use the windows to check if there is enough insulin left for proper mixing. For users of Novolin 70/30 or Novolin N insulin: Always remix the insulin. To remix the insulin, turn the NovoPen 3 up and down between positions A and B 10 times or until the insulin looks uniformly white and cloudy.

SECTION 3 (cont.) Wipe the front rubber stopper with an alcohol swab. You must wipe the front rubber stopper with an alcohol swab before each injection, even if you are using the same PenFill cartridge. Never place a NovoFine disposable needle on your NovoPen 3 until you are ready to do an air shot and give an injection. If the NovoFine needle is “left on, ” some liquid may leak out of the PenFill cartridge.

SECTION 4 Doing an Air Shot To prevent the injection of air Before starting the air shot and make certain insulin is procedure, the dose delivered, you must do an air indicator window must shot before each injection. Show zero (0). If you use Novolin 70/30 or Novolin N insulin and have used the Novolin PenFill. SECTION 4 (cont.) Set the NovoPen 3 for the air shot: Turn the dial-a-dose selector to 2 units. The even numbers are shown.

The odd numbers are indicated by the long lines between the even numbers. If you dial more than 2 units, DO NOT turn the dial back to zero (0). Uncap the NovoFine needle: Pull off the outer needle cap and set aside. Pull off the inner needle cap and discard. Hold the NovoPen 3 with the NovoFine needle pointing upward. Tap the cartridge holder with your finger a few times to.

SECTION 4 (cont.) Do the air shot: Press the push button all the way in. Insulin should appear at the needle tip. If no insulin appears, repeat the following steps, until insulin appears: a. Make sure the NovoFine needle is securely attached. DO NOT use the clicking sounds as a guide for selecting your dose. The NovoPen 3 can deliver from 2 to 70 units of insulin, in 1-unit increments.

If you dial more than your dose, DO NOT turn the dial back to zero (0). If you do, the extra insulin will squirt out of the needle. SECTION 5 (cont.) To reset to zero (0) if you set the wrong dose: a. Grasp the cartridge holder with your thumb and forefinger. Grasp the barrel between your thumb and middle finger. Pull the cartridge holder down from the barrel as far as it will go (arrow #1).

SECTION 5 (cont.) Give the injection: Insert the NovoFine needle in the correct site on the body. (Use the injection technique recommended by your health care professional.) Press the push button as far as it will go to deliver the insulin. SECTION 5 (cont.) To get the remaining part If the dose indicator window of your dose: does not show zero, there were not enough units of insulin in a.

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Note the number of units in the PenFill cartridge for you to the dose indicator window. SECTION 6 Removing the NovoFine Disposable Needle Remove the NovoFine disposable needle: Carefully replace the outer needle cap. Hold the cartridge holder firmly while you unscrew the NovoFine disposable needle. Place the NovoFine disposable needle in a puncture-resistant disposable container.

The NovoFine disposable needle must be removed immediately after each injection. SECTION 6 (cont.) Replace the pen cap: Hold the pen cap so that the clip is lined up with the dose indicator window. Gently slide the pen cap onto the barrel. PenFill cartridge for proper mixing. Remove the barrel: Remove the pen cap. Hold the NovoPen 3 with the dose indicator window at the top. Unscrew the barrel from the cartridge holder.

SECTION 7 (cont.) Remove the PenFill 3 mL cartridge: Tip the cartridge holder. The PenFill cartridge will drop out. Press the push button all the way in until zero (0) appears in the window. Turn the end of the reset mechanism in a clockwise direction until the piston rod is no longer sticking out.

You will not be injecting insulin into your body. Always check the functioning of the NovoPen 3 if you suspect it has been damaged or if you are uncertain that it is delivering the correct dose. FUNCTION CHECK (cont.) Place the outer needle cap securely over the exposed NovoFine needle.

Do not replace the inner needle cap. Expel 20 units into the outer needle cap: Turn the dial-a-dose selector so the dose indicator window shows 20. If the second function check also shows under- or over- filling, do not use your NovoPen 3.

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DO NOT try to repair a NovoPen 3 that you think is not working properly. (See Warranty section for further information.). Store the NovoPen 3 (with the PenFill cartridge inside) NovoPen 3 and PenFill 3 mL cartridges: at room temperature. Do not store the NovoPen 3 in a refrigerator or areas where there may be extreme temperatures or moisture, such as your car. MAINTENANCE Be sure to: Guidelines for maintaining the NovoPen 3.

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Clean it by wiping with a soft cloth moistened with alcohol. Protect it from dust, dirt, and moisture when not in its case. Make certain you: Do not soak it in alcohol. NovoFine If you use more than one type single-use disposable (N, R or 70/30) of insulin, needles or other products use a separate NovoPen 3 for specifically recommended each type.

By Novo Nordisk. Use only a new PenFill. To always do the air shot using the number in the with the NovoFine needle dose indicator window. Pointing upward. Perform the function check regularly or if you think your NovoPen 3 is not working properly.

Call 1-800-727-6500. IMPORTANT NOTES (cont.) Make certain you: DO NOT place a NovoFine DO NOT use the same needle on the NovoPen 3 PenFill cartridge for more until you are ready to do an than one person, even though air shot and give an injection you attach a new NovoFine or perform a function check. WHAT TO DO IF The dose indicator window The piston rod is sticking does not show zero after out too far to attach the car- the injection: tridge holder to the barrel: You did not receive your You must screw the piston full dose. Novo Nordisk Pharmaceuticals, Inc. The use of the NovoPen 3 Product Safety with products other than 100 Overlook Center PenFill 3 mL cartridges, Suite 200. For assistance or further information, write to: Novo Nordisk Pharmaceuticals, Inc.

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Professional Services 100 Overlook Center Suite 200 Princeton, NJ Or call: 1-800-727-6500 NovoPen, Novolin, PenFill ® ® ® NovoFine are registered trademarks ® of Novo Nordisk A/S.